Dr. Mariya-al-Rashida
Faculty
EXT | 601
mariyarashida@fccollege.edu.pk

DEPARTMENT OF CHEMISTRY

Ph.D. (University of the Punjab, Lahore)

Dr. Mariya al-Rashida did her Ph.D. in Chemistry in 2011 from the Institute of Chemistry, University of the Punjab, Lahore, Pakistan as an HEC Scholar (Indigenous Scholarship, Batch III). She is currently working as a Professor
& Chairperson at the Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan. Her area of research is synthetic & computational medicinal chemistry, she has published 85 (including 03 crystal structure reports) in international peer-reviewed journals and has an impact factor of 368.649 (2021 JCR). She has one US Patent to her credit (US-Patent No. 9643169). Dr. Mariyaal-Rashida has two ongoing HEC funded NRPU Research Projects worth Rs. 3.9 and 3.7 million. Currently, her research is focused on ionic liquid and deep eutectic solvent-mediated synthesis of novel compounds, and exploring their biological activities as inhibitors of metalloenzymes (carbonic anhydrase, ectonucleotidases), and monoamine oxidase. She has been the recipient of the Research Productivity Award, awarded by the Pakistan Council for Science and Technology (PCST), for the years 2015 and 2016. She was awarded IUCr Young Scientist Award, sponsored by The International Union of Crystallography (IUCr) in 2016.

Research Interests:

Synthetic and computational medicinal chemistry, ionic liquid and deep eutectic solvent-mediated synthesis of biologically active molecules, synthesis of small molecules as ion sensors, synthesis of inhibitors of metalloenzymes, DNA interaction, and molecular docking studies

Patent:

1. Process for the Preparation of Quinoline Based Ionic Fluoride Salts (QUFs).
A. Hameed, N. Iqbal, J. Hashim, K. M. Khan, S. T. Moin, S. Ahmad, S. A. Ali, F. Z. Basha, M. al-Rashida, R. D. Alharthy, S. Perveen, US-Patent No. 9643169, Application No. 15.158,867, Patent Date 09/05/2017.

2. Pyridine Based Ionic Fluoride for Catalyzing Indole and Tetrazole Formation. Ghumro, S. A., Alharthy, R. D., Saleem, S., Al-Rashida, M. , Iqbal, N., Ahmed, S. A., Syed A., Moin, S.T., Hameed, A. United States Patent Application 20190375711 (2019)

Memberships:

Life Member Chemical Society of Pakistan.

Editorship:

  1. Guest Editor for Special Issue “Recent Developments of Carbonic Anhydrase Inhibitors as potential Drugs” in BioMed Research International.
  2. Review Editor of Frontiers in Chemistry (Medicinal and Pharmaceutical Chemistry section) from 2015-2018.
  3. Academic Editor of PLOS One since March 2019.

ResearchGate Profile

Funded Research Projects:

  1. Research project titled, “Ionic Liquid Mediated Multicomponent Reactions (MCRs) for Synthesis of
    Biologically Active Heterocyclic Compounds: Synthesis, Structural Elucidation and Evaluation of Biological Activities Targeting Neurodegenerative Diseases    ” of Rs 3.7 million, by Higher Education Commission of Pakistan (HEC) under National Research Program for Universities (NRPU). Year awarded: 2018.
  2. Research project titled, “Synthesis of Novel Sulfonamide Derivatives as Inhibitors of Ectonucleotidases” of 3.9 Million Rs., by Higher Education Commission of Pakistan (HEC) under National Research Program for Universities (NRPU) [project No. 20-3133/NRPU/R&D/HEC/13/675]. Year awarded: 2015; year completed: 2018.
    [completed, final report submitted]

Selected Publications:

  1. Jamshed Iqbal, Syeda Abida Ejaz, Aamer Saeed, Mariya al-Rashida. Detailed investigation of anticancer activity of sulfamoyl benz (sulfon) amides and 1H-pyrazol-4-yl benzamides: An experimental and computational study. Eur J Pharmacol. 2018;832:11-24. (IF 2017 = 3.040).
  2. Mariya al-Rashida, Gazala Batool, Almas Sattar, Syeda Abida
    Ejaz, Samiullah Khan, Joanna Lecka, Jean Sévigny, Abdul Hameed, Jamshed
    Iqbal. 2-Alkoxy-3-(sulfonylarylaminomethylene)-chroman-4-ones as potent and selective inhibitors of ectonucleotidases. Eur J Med Chem. 2016;115:484-94. (IF 2017 = 4.816).
  3. Mariya Al-Rashida, Sana Ahsen. In search of a docking protocol to distinguish between DNA intercalators
    and groove binders: Genetic algorithm vs. shape-complementarity based docking methods    . RSC Adv., 2015;5:72394-72404. (IF 2017 = 2.936).
  4. Mariya al-Rashida, Syeda Abida Ejaz, Sharafat Ali, Aisha
    Shaukat, Mehwish Hamayoun, Maqsood Ahmed, Jamshed Iqbal.Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase.Bioorg. Med Chem. 2015;15;23(10):2435-44.(IF 2017 = 2.881).
  5. Mariya al-Rashida, Jamshed Iqbal.Therapeutic Potentials of Ecto-Nucleoside Triphosphate Diphosphohydrolase, Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase, Ecto-5′-Nucleotidase, and Alkaline Phosphatase Inhibitors. Med Res Rev 2013;34(4):703-43. (IF 2017 = 8.29).
  6. Mariya-al-Rashida, Rabia Raza, Ghulam Abbas, Muhammad Shakil Shah, George E. Kostakis, Joanna Lecka, Jean Sévigny, Muhammad Muddassar, Constantina Papatriantafyllopoulou, Jamshed Iqbal. Identification of Novel Chromone Based Sulfonamides as Highly Potent and
    Selective Inhibitors of Alkaline Phosphatases.     Eur J Med Chem 2013;66:438-449. (IF 2017 = 4.816).

Research Achievements & Awards

  1. Awarded CSP Gold Medal for Chemist Under 40, by the prestigious Chemical Society of Pakistan (CSP) in 2019.
  2. Won Research Productivity Award (RPA) 2016, awarded by Pakistan Council of Science & Technology (PCST), in category D.
  3. Won IUCr Young Scientist Award sponsored by The International Union of Crystallography (IUCr) at four-day international
    workshop “X-ray Crystallography in Structural Biology” held at FCCU on 15-18th Oct, 2016.
  4. Won Research Productivity Award (RPA) 2015, awarded by Pakistan Council of Science & Technology (PCST), in category C.

Authored Books

  1. α-Tertiary Amines en Route to Natural Products. 1st Edition (2021). Elsevier. Authors: Abdul Hameed, Mariya al-Rashida, Muhammad Raza Shah. Paperback ISBN: 9780128222621
  2. Contributed a book chapter titled, “Ionic liquid-based colloidal nanoparticles: applications in organic synthesis” by Marium Ishtiaq, Mariya al-Rashida, Rima D. Alharthy and Abdul Hameed, in book titled, “Metal nanoparticles for drug delivery and diagnostic applications”. Editors: Muhammad Raza Shah Muhammad Imran Shafi Ullah. Elsevier, Oct 2019. eBook ISBN: 9780128169612
Research Area
Address
ROOM | 164, Armacost Science Building
Dr. Mariya-al-Rashida
Faculty
EXT | 601
mariyarashida@fccollege.edu.pk

DEPARTMENT OF CHEMISTRY

Ph.D. (University of the Punjab, Lahore)

Dr. Mariya al-Rashida did her Ph.D. in Chemistry in 2011 from the Institute of Chemistry, University of the Punjab, Lahore, Pakistan as an HEC Scholar (Indigenous Scholarship, Batch III). She is currently working as a Professor
& Chairperson at the Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan. Her area of research is synthetic & computational medicinal chemistry, she has published 85 (including 03 crystal structure reports) in international peer-reviewed journals and has an impact factor of 368.649 (2021 JCR). She has one US Patent to her credit (US-Patent No. 9643169). Dr. Mariyaal-Rashida has two ongoing HEC funded NRPU Research Projects worth Rs. 3.9 and 3.7 million. Currently, her research is focused on ionic liquid and deep eutectic solvent-mediated synthesis of novel compounds, and exploring their biological activities as inhibitors of metalloenzymes (carbonic anhydrase, ectonucleotidases), and monoamine oxidase. She has been the recipient of the Research Productivity Award, awarded by the Pakistan Council for Science and Technology (PCST), for the years 2015 and 2016. She was awarded IUCr Young Scientist Award, sponsored by The International Union of Crystallography (IUCr) in 2016.

Research Interests:

Synthetic and computational medicinal chemistry, ionic liquid and deep eutectic solvent-mediated synthesis of biologically active molecules, synthesis of small molecules as ion sensors, synthesis of inhibitors of metalloenzymes, DNA interaction, and molecular docking studies

Patent:

1. Process for the Preparation of Quinoline Based Ionic Fluoride Salts (QUFs).
A. Hameed, N. Iqbal, J. Hashim, K. M. Khan, S. T. Moin, S. Ahmad, S. A. Ali, F. Z. Basha, M. al-Rashida, R. D. Alharthy, S. Perveen, US-Patent No. 9643169, Application No. 15.158,867, Patent Date 09/05/2017.

2. Pyridine Based Ionic Fluoride for Catalyzing Indole and Tetrazole Formation. Ghumro, S. A., Alharthy, R. D., Saleem, S., Al-Rashida, M. , Iqbal, N., Ahmed, S. A., Syed A., Moin, S.T., Hameed, A. United States Patent Application 20190375711 (2019)

Memberships:

Life Member Chemical Society of Pakistan.

Editorship:

  1. Guest Editor for Special Issue “Recent Developments of Carbonic Anhydrase Inhibitors as potential Drugs” in BioMed Research International.
  2. Review Editor of Frontiers in Chemistry (Medicinal and Pharmaceutical Chemistry section) from 2015-2018.
  3. Academic Editor of PLOS One since March 2019.

ResearchGate Profile

Funded Research Projects:

  1. Research project titled, “Ionic Liquid Mediated Multicomponent Reactions (MCRs) for Synthesis of
    Biologically Active Heterocyclic Compounds: Synthesis, Structural Elucidation and Evaluation of Biological Activities Targeting Neurodegenerative Diseases    ” of Rs 3.7 million, by Higher Education Commission of Pakistan (HEC) under National Research Program for Universities (NRPU). Year awarded: 2018.
  2. Research project titled, “Synthesis of Novel Sulfonamide Derivatives as Inhibitors of Ectonucleotidases” of 3.9 Million Rs., by Higher Education Commission of Pakistan (HEC) under National Research Program for Universities (NRPU) [project No. 20-3133/NRPU/R&D/HEC/13/675]. Year awarded: 2015; year completed: 2018.
    [completed, final report submitted]

Selected Publications:

  1. Jamshed Iqbal, Syeda Abida Ejaz, Aamer Saeed, Mariya al-Rashida. Detailed investigation of anticancer activity of sulfamoyl benz (sulfon) amides and 1H-pyrazol-4-yl benzamides: An experimental and computational study. Eur J Pharmacol. 2018;832:11-24. (IF 2017 = 3.040).
  2. Mariya al-Rashida, Gazala Batool, Almas Sattar, Syeda Abida
    Ejaz, Samiullah Khan, Joanna Lecka, Jean Sévigny, Abdul Hameed, Jamshed
    Iqbal. 2-Alkoxy-3-(sulfonylarylaminomethylene)-chroman-4-ones as potent and selective inhibitors of ectonucleotidases. Eur J Med Chem. 2016;115:484-94. (IF 2017 = 4.816).
  3. Mariya Al-Rashida, Sana Ahsen. In search of a docking protocol to distinguish between DNA intercalators
    and groove binders: Genetic algorithm vs. shape-complementarity based docking methods    . RSC Adv., 2015;5:72394-72404. (IF 2017 = 2.936).
  4. Mariya al-Rashida, Syeda Abida Ejaz, Sharafat Ali, Aisha
    Shaukat, Mehwish Hamayoun, Maqsood Ahmed, Jamshed Iqbal.Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase.Bioorg. Med Chem. 2015;15;23(10):2435-44.(IF 2017 = 2.881).
  5. Mariya al-Rashida, Jamshed Iqbal.Therapeutic Potentials of Ecto-Nucleoside Triphosphate Diphosphohydrolase, Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase, Ecto-5′-Nucleotidase, and Alkaline Phosphatase Inhibitors. Med Res Rev 2013;34(4):703-43. (IF 2017 = 8.29).
  6. Mariya-al-Rashida, Rabia Raza, Ghulam Abbas, Muhammad Shakil Shah, George E. Kostakis, Joanna Lecka, Jean Sévigny, Muhammad Muddassar, Constantina Papatriantafyllopoulou, Jamshed Iqbal. Identification of Novel Chromone Based Sulfonamides as Highly Potent and
    Selective Inhibitors of Alkaline Phosphatases.     Eur J Med Chem 2013;66:438-449. (IF 2017 = 4.816).

Research Achievements & Awards

  1. Awarded CSP Gold Medal for Chemist Under 40, by the prestigious Chemical Society of Pakistan (CSP) in 2019.
  2. Won Research Productivity Award (RPA) 2016, awarded by Pakistan Council of Science & Technology (PCST), in category D.
  3. Won IUCr Young Scientist Award sponsored by The International Union of Crystallography (IUCr) at four-day international
    workshop “X-ray Crystallography in Structural Biology” held at FCCU on 15-18th Oct, 2016.
  4. Won Research Productivity Award (RPA) 2015, awarded by Pakistan Council of Science & Technology (PCST), in category C.

Authored Books

  1. α-Tertiary Amines en Route to Natural Products. 1st Edition (2021). Elsevier. Authors: Abdul Hameed, Mariya al-Rashida, Muhammad Raza Shah. Paperback ISBN: 9780128222621
  2. Contributed a book chapter titled, “Ionic liquid-based colloidal nanoparticles: applications in organic synthesis” by Marium Ishtiaq, Mariya al-Rashida, Rima D. Alharthy and Abdul Hameed, in book titled, “Metal nanoparticles for drug delivery and diagnostic applications”. Editors: Muhammad Raza Shah Muhammad Imran Shafi Ullah. Elsevier, Oct 2019. eBook ISBN: 9780128169612
Research Area
Address
ROOM | 164, Armacost Science Building
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